Female infertility continues to increase in prevalence annually and factors causing it need to be researched. As IL-6-174 G/C polymorphism is known to alter the plasma levels of IL-6, abnormal levels of IL-6 found in infertile females could be due to genetic reasons. With the understanding of the importance of IL-6 in reproductive physiology, several individual studies done so far to find the association of this polymorphism with female infertility related disorders were systematically combined for meta-analysis. Articles were searched using electronic data base sources and were included based on specific criteria. Finally, eight articles which includes polycystic ovarian syndrome (PCOS; n = 4), endometriosis (n = 3) and tubal damage (n = 1) were selected for the analysis. Results showed statistically significant heterogeneity across studies under the allele model (p < 0.0001, I2 = 78 %) and dominant model (p < 0.00001, I2 = 82%) but not under recessive model (p = 0.31, I2 = 16%). This difference could be possibly due to variation in ethnicity, lifestyle, age or BMI related factors. The pooled odds ratio under the three genetic models were 0.87(CI = 0.75-1.02), 0.77 (CI = 0.63-0.94) and 1.05 (CI = 0.76-1.46) respectively. Sub group analysis showed statistical significant (P < 0.01) for PCOS under allele and dominant model, but not for endometriosis and tubal damage. By this meta-analysis, we can say that IL-6-174 G/C polymorphism can be considered as a potential genetic marker for PCOS but not for endometriosis and tubal damage disorders. However, more studies with adequate sample sizes are required to be done in endometriosis, tubal disease and other female infertility disorders to arrive at a definite conclusion.

中文翻译：

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il-6-174 g/c 多态性与女性不育相关疾病关联的荟萃分析。

女性不孕症的患病率每年都在持续增加，需要研究导致不孕症的因素。由于已知 IL-6-174 G/C 多态性会改变 IL-6 的血浆水平，因此在不育女性中发现的 IL-6 水平异常可能是由于遗传原因。随着对 IL-6 在生殖生理学中的重要性的理解，迄今为止为发现这种多态性与女性不育相关疾病的关联而进​​行的几项单独研究被系统地结合起来进行荟萃分析。文章使用电子数据库资源进行搜索，并根据特定标准纳入。最后，选择了包括多囊卵巢综合征（PCOS；n = 4）、子宫内膜异位症（n = 3）和输卵管损伤（n = 1）在内的八篇文章进行分析。结果显示在等位基因模型（p < 0.0001，I2 = 78%）和显性模型（p < 0.00001，I2 = 82%）下的研究之间存在统计学显着的异质性，但在隐性模型（p = 0.31，I2 = 16%）下没有。这种差异可能是由于种族、生活方式、年龄或 BMI 相关因素的差异造成的。三种遗传模型下的汇总优势比分别为 0.87（CI = 0.75-1.02）、0.77（CI = 0.63-0.94）和 1.05（CI = 0.76-1.46）。亚组分析显示等位基因和显性模型下PCOS具有统计学意义（P < 0.01），但对子宫内膜异位症和输卵管损伤没有统计学意义。通过这项荟萃分析，我们可以说 IL-6-174 G/C 多态性可以被认为是 PCOS 的潜在遗传标记，但不是子宫内膜异位症和输卵管损伤疾病的潜在遗传标记。然而，