The skin is inhabited by several immune cell populations that serve as a first line of defence against pathogen invasion. Amongst these populations are dendritic cells, which play an essential sentinel function by taking up antigen or infectious agents and transporting them to the lymph node for T cell recognition and the priming of immune responses. In this review, we briefly summarise recent advances showing how skin dendritic cells are connected to a network of epithelial and stromal cells, which provide structural support, growth factors, spatial cues, contact with the external environment and the skin microbiome, and favour interactions with other immune cells. We propose that this network creates a unique skin environment that may condition dendritic cell phenotype and function.

中文翻译：

---

树突状细胞和皮肤环境。

皮肤上有几个免疫细胞群，作为抵御病原体入侵的第一道防线。在这些群体中，有树突状细胞，它们通过吸收抗原或感染因子并将它们运送到淋巴结以进行 T 细胞识别和免疫反应的启动，从而发挥重要的哨兵功能。在这篇综述中，我们简要总结了最近的进展，显示了皮肤树突细胞如何与上皮细胞和基质细胞网络连接，这些细胞提供结构支持、生长因子、空间线索、与外部环境和皮肤微生物组的接触，并有利于与其他免疫细胞。我们建议这个网络创造了一个独特的皮肤环境，可以调节树突状细胞的表型和功能。