This systematic review analyzed the light parameters and the effects of photobiomodulation therapy (PBMT) through low‐level laser therapy (LLLT) and/or LED (light‐emitting diode) on tendon repair of rats submitted to calcaneal injury. This study was conducted in accordance with the guidelines of the Preferred Reporting Items for Meta‐Analysis, and PubMed and MEDLINE databases were accessed to search eligible studies published in English. The search terms were as follows: "Achilles tendon" or "Calcaneal tendon" or "tendon injuries" or "soft tissue injuries" and "tendinopathy" or "tendinitis" and "low‐level light therapy" or "low‐level laser therapy" or "low intensity power therapy" or "light‐emitting diode" or photobiomodulation." The SYRCLE (SYstematic Review Center for Laboratory animal Experimentation) risks of bias was used to assess the risk of bias for selected studies. A total of 225 studies were found based on the descriptors used, and only 33 studies were eligible. Light parameters identified per point of irradiation were approximately 60 mW (continuous mode at infrared spectra), 2 W cm−2, 2 J and 45 J cm−2. Light parameters at red spectra, continuous versus pulsed mode, and PBMT combined or compared with other therapies such as ultrasound, and studies using unhealthy rats (ovariectomized and/or diabetic models) were also identified and grouped according to these similarities. The main effects found were decreased inflammatory markers and signs of inflammatory process. PBMT (laser/LED) has positive effects in reducing the inflammatory and time for tissue repair in animal models of tendon injury and/or tendinitis using parameters identified.

中文翻译：

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光生物调节疗法（PBMT）对大鼠实验性跟腱损伤的系统评价

本系统评价分析了光参数和光生物调节疗法 (PBMT) 通过低强度激光疗法 (LLLT) 和/或 LED（发光二极管）对跟骨损伤大鼠肌腱修复的影响。本研究按照 Meta 分析首选报告项目的指南进行，并访问 PubMed 和 MEDLINE 数据库以搜索以英文发表的符合条件的研究。搜索词如下：“跟腱”或“跟腱”或“肌腱损伤”或“软组织损伤”和“肌腱病”或“肌腱炎”和“低强度光疗法”或“低强度激光疗法” ”或“低强度功率疗法”或“发光二极管”或光生物调节。SYRCLE（实验室动物实验系统评价中心）的偏倚风险用于评估选定研究的偏倚风险。根据所使用的描述符共找到 225 项研究，只有 33 项研究符合条件。每个照射点确定的光参数约为 60 mW（红外光谱的连续模式）、2 W cm-2、2 J 和 45 J cm-2。红光谱的光参数、连续模式与脉冲模式、PBMT 结合或与其他疗法（如超声）进行比较，以及使用不健康大鼠（去卵巢和/或糖尿病模型）的研究也根据这些相似性进行了识别和分组。发现的主要作用是减少炎症标志物和炎症过程的迹象。