The recently published chronotherapeutic Spanish papers MAPEC and HYGIA proposing that antihypertensive drug treatment should be given at bedtime suffers from obvious deficiencies in study design and are not a valid basis for drug treatment of hypertension.

中文翻译：

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西班牙高血压研究MAPEC和HYGIA的评论。

西班牙最近发表的计时疗法论文MAPEC和HYGIA提出应在就寝时给予降压药物治疗，这在研究设计中存在明显的缺陷，并且不是高血压药物治疗的有效依据。