Isolated REM sleep behaviour disorder (iRBD) is a predictive marker of prodromal Lewy body disease. iRBD prevalence in the general population is around 1%, but it remains under-diagnosed, even though symptoms are alleviated by medication. We developed a population screening strategy and identified 16 iRBD patients by conducting telephone interviews and polysomnography examinations. We compared our population-screened cohort with sleep-center referred patients and found higher MoCA scores and lower MDS-UPDRS-III scores in our patients. In conclusion, screening can be used to identify iRBD patients in a cost-effective manner with the benefit of identifying patients at a very early disease stage.

中文翻译：

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在丹麦社区环境中识别 REM 睡眠行为障碍患者的基于筛查的方法。

孤立性快速眼动睡眠行为障碍 (iRBD) 是前驱路易体病的预测标志物。iRBD 在一般人群中的患病率约为 1%，但即使通过药物缓解症状，它仍然未得到充分诊断。我们制定了一项人群筛查策略，并通过电话采访和多导睡眠图检查确定了 16 名 iRBD 患者。我们将我们的人群筛查队列与睡眠中心转诊的患者进行了比较，发现我们患者的 MoCA 评分较高，MDS-UPDRS-III 评分较低。总之，筛查可用于以具有成本效益的方式识别 iRBD 患者，并有利于在非常早期的疾病阶段识别患者。