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Pharmacotherapy Use for Non-Motor Symptoms Among de novo Parkinson's Disease Parkinson's Progression Markers Initiative Participants.
Journal of Parkinson’s Disease ( IF 5.2 ) Pub Date : 2020-01-01 , DOI: 10.3233/jpd-201973
Monica Javidnia 1, 2 , Ira Shoulson 1, 2 , Karl Kieburtz 1, 2 , Charles S Venuto 1, 2
Affiliation  

Parkinson's disease (PD) patients experience a range of non-motor symptoms that are believed to be related to disease pathophysiology, many of which are treatable by medications. Among newly-diagnosed PD participants in the Parkinson's Progression Markers Initiative study, we describe (1) the frequency of medication use for common non-motor symptoms, and (2) when non-motor symptomatic treatment was initiated relative to PD diagnosis. Non-motor medication use was reported by 73% of participants, most commonly for depression, constipation, and anxiety. Treatment of some non-motor symptoms, notably depression, antedated diagnosis. These data may be useful for studies of non-motor symptoms in PD.

中文翻译:

新发帕金森病帕金森病进展标志物倡议参与者中非运动症状的药物治疗用途。

帕金森病 (PD) 患者会出现一系列非运动症状,这些症状被认为与疾病病理生理学有关,其中许多可以通过药物治疗。在帕金森病进展标志物倡议研究中新诊断的 PD 参与者中,我们描述了 (1) 常见非运动症状的药物使用频率,以及 (2) 相对于 PD 诊断,何时开始非运动对症治疗。73% 的参与者报告了非运动药物的使用,最常见的是抑郁、便秘和焦虑。治疗一些非运动症状,特别是抑郁症,早于诊断。这些数据可能有助于研究 PD 中的非运动症状。
更新日期:2020-05-15
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