Aim and Objective: Esophageal squamous cell carcinoma (ESCC) is the most prevalent type of cancer with worldwide distribution and dismal prognosis despite ongoing efforts to improve treatment options. Therefore, it is essential to determine the prognostic factors for ESCC.

Methods and Results: We determined KLRB1 to be a prognostic indicator of human ESCC. KLRB1 was expressed at low levels in ESCC patients. Based on the risk score, patients were divided into high and low-risk groups. High-risk patients showed a poor survival rate. The prediction model based on the N stage, sex, and KLRB1 was significantly better than that based on the N stage and sex. The modified prediction model showed a robust ROC curve with an AUC value of 0.973. The knockdown of KLRB1 inhibited the growth of human ESCC cells. KLRB1 regulated Akt, mTOR, p27, p38, NF-κB, Cyclin D1, and JNK signaling, which was consistent with the result of GSEA.

Conclusion: KLRB1 is a potential prognostic marker for human ESCC patients.

目的和目的：尽管人们不断努力改善治疗方案，但食管鳞状细胞癌（ESCC）是最普遍的癌症，其分布范围广泛且预后不良。因此，确定ESCC的预后因素至关重要。

方法和结果：我们确定KLRB1是人类ESCC的预后指标。在ESCC患者中KLRB1以低水平表达。根据风险评分，将患者分为高风险组和低风险组。高危患者的生存率较差。基于N期，性别和KLRB1的预测模型明显优于基于N期和性别的预测模型。修改后的预测模型显示出稳健的ROC曲线，AUC值为0.973。敲低KLRB1抑制人类ESCC细胞的生长。KLRB1调节Akt，mTOR，p27，p38，NF-κB，Cyclin D1和JNK信号传导，这与GSEA的结果一致。

结论：KLRB1是人类ESCC患者的潜在预后标志物。