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β-Defensin Strengthens Antimicrobial Peritoneal Mast Cell Response.
Journal of Immunology Research ( IF 4.1 ) Pub Date : 2020-04-27 , DOI: 10.1155/2020/5230172
Justyna Agier 1 , Ewa Brzezińska-Błaszczyk 1 , Sylwia Różalska 2 , Magdalena Wiktorska 3 , Sebastian Wawrocki 4 , Paulina Żelechowska 1
Affiliation  

Mast cells (MCs) are engaged in the processes of host defense, primarily via the presence of receptors responsible for the detection of pathogen-associated molecular patterns (PAMPs). Since BDs are exclusively host defense molecules, and MCs can elicit the antimicrobial response, this study is aimed at determining whether BDs might be involved in MC pathogen defense. We found that defensin BD-2 significantly augments the mRNA and protein expression of Toll-like receptors (TLRs) and retinoic acid-inducible gene-I-like receptor (RLR) essential for the detection of viral molecules, i.e., TLR3, TLR7, TLR9, and RIG-I in mature tissue rat peritoneal MCs (PMCs). We established that BD-2 might stimulate PMCs to release proinflammatory and immunoregulatory mediators and to induce a migratory response. Presented data on IgE-coated PMC upon BD-2 treatment suggest that in the case of allergies, there is an enhanced MC immune response and cell influx to the site of the ongoing infection. In conclusion, our data highlight that BD-2 might strongly influence MC features and activity, mainly by strengthening their role in the inflammatory mechanisms and controlling the activity of cells participating in antimicrobial processes.

中文翻译:

β-防御素可增强抗菌性腹膜肥大细胞反应。

肥大细胞(MC)主要通过存在负责检测病原体相关分子模式(PAMP)的受体参与宿主防御过程。由于BD仅是宿主防御分子,而MC可以引起抗菌反应,因此本研究旨在确定BD是否可能参与MC病原体防御。我们发现防御素BD-2显着增强了Toll样受体(TLR)和视黄酸诱导型基因I样受体(RLR)的mRNA和蛋白表达,这对于检测病毒分子(即TLR3,TLR7, TLR9和RIG-1在成熟组织大鼠腹膜MC(PMC)中。我们确定BD-2可能刺激PMC释放促炎和免疫调节介质并诱导迁移反应。有关BD-2治疗后IgE包被的PMC的现有数据表明,在过敏的情况下,MC免疫反应增强,并且细胞流入正在进行的感染部位。总之,我们的数据突出表明BD-2可能主要通过增强其在炎症机制中的作用和控制参与抗菌过程的细胞的活性来强烈影响MC的特征和活性。
更新日期:2020-04-27
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