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Biocatalysis in drug discovery and development.
Current Opinion in Chemical Biology ( IF 7.8 ) Pub Date : 2020-03-10 , DOI: 10.1016/j.cbpa.2020.01.012
Anna Fryszkowska 1 , Paul N Devine 1
Affiliation  

Enzyme catalysis, enabled by advances in protein engineering and directed evolution, is beginning to transform chemical synthesis in the pharmaceutical industry. This review presents recent examples of the creative use of biocatalysis to enable drug discovery and development. We illustrate how increased access to novel biotransformations and the rise of cascade biocatalysis allowed fundamentally new syntheses of novel medicines, representing progress toward more sustainable pharmaceutical manufacturing. Finally, we describe the opportunities and challenges the industry must address to ensure the reduction to practice of biotechnological innovations to develop new therapies in a faster, more economical, and environmentally benign way.

中文翻译:

药物发现和开发中的生物催化。

通过蛋白质工程的发展和定向进化而实现的酶催化,正在开始改变制药行业的化学合成方法。这篇综述提供了生物催化创新用途的最新实例,以实现药物的发现和开发。我们说明了增加获得新型生物转化的途径和级联生物催化的兴起如何从根本上实现了新型药物的新合成,代表了朝着更可持续的制药生产方向发展。最后,我们描述了该行业必须解决的机遇和挑战,以确保减少生物技术创新的实践,从而以更快,更经济,更环保的方式开发新疗法。
更新日期:2020-03-10
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