Background: Granular cell tumors (GCTs) or Abrikossoff’s tumors are rare neoplasms known to originate from Schwann cells in the peripheral nervous system. These lesions are usually benign; malignancy only occurs in 1–2% of cases. Surgical resection is the traditional treatment method for GCTs, but it poses several risks and disadvantages related to the surgical incompatibility of the patient, the extended recovery time, and the chance of relapse. Cryoablation is becoming an increasingly favored method of treatment for tumors, both benign and malignant, due to its minimal invasiveness, natural analgesic properties, and ability to stimulate antitumor immunity. Cryoablation may contribute to the prevention of secondary and metastatic tumor growth in cases of malignancy by preserving tumor-associated antigen molecules for recognition by cell-mediated immunity. Methods: This article describes a novel method for GCT treatment using cryoablation. This technique exposes tumor tissue to extreme cold temperatures, effectively destroying tumor cells by irreversibly compromising their plasma membranes. To our knowledge, this is the first report in the literature of cryoablative techniques being used for GCT. Results: Cryoablation of this mass was successful with no complications. CT images during the procedure demonstrated circumferential coverage of the entire lesion with no injury to the surrounding tissues. Conclusion: Cryoablation can be used as an alternative to surgical intervention to treat malignant GCTs. This procedure is minimally invasive, less painful, and potentially effective in promoting antitumor immunity.
Gastrointest Tumors 2020;7:41–49

中文翻译：

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罕见肿瘤的罕见治疗：颗粒细胞肿瘤的冷冻消融。

背景：颗粒细胞瘤 (GCT) 或 Abrikossoff 肿瘤是已知起源于周围神经系统中的雪旺细胞的罕见肿瘤。这些病变通常是良性的；恶性肿瘤仅发生在 1-2% 的病例中。手术切除是GCTs的传统治疗方法，但存在患者手术不适应、恢复时间延长和复发机会等诸多风险和缺点。由于其微创性、天然镇痛特性和刺激抗肿瘤免疫的能力，冷冻消融正成为一种越来越受欢迎的治疗良性和恶性肿瘤的方法。冷冻消融可以通过保存肿瘤相关抗原分子以供细胞介导的免疫识别，从而有助于预防恶性肿瘤病例中的继发性和转移性肿瘤生长。方法：本文介绍了一种使用冷冻消融进行 GCT 治疗的新方法。这种技术将肿瘤组织暴露在极冷的温度下，通过不可逆地损害它们的质膜来有效地破坏肿瘤细胞。据我们所知，这是用于 GCT 的冷冻消融技术文献中的第一份报告。结果：这个肿块的冷冻消融是成功的，没有并发症。手术过程中的 CT 图像显示整个病灶的周向覆盖，对周围组织没有损伤。结论：冷冻消融可作为手术干预的替代方法来治疗恶性 GCT。该程序是微创的，痛苦较小，并且在促进抗肿瘤免疫方面可能有效。
胃肠肿瘤 2020；7:41–49