Objective. To evaluate the electrochemical properties, biological response, and surface characterization of an electrodeposited Platinum-Iridium (Pt-Ir) electrode coating on cochlear implants subjected to chronic stimulation in vivo. Approach . Electrochemical impedance spectroscopy (EIS), charge storage capacity (CSC), charge injection limit (CIL), and voltage transient (VT) impedance were measured bench-top before and after implant and in vivo . Coated Pt-Ir and uncoated Pt electrode arrays were implanted into cochlea of normal hearing rats and stimulated for ∼4 h d, 5 d week −1 for 5 weeks at levels within the normal clinical range. Neural function was monitored using electrically-evoked auditory brainstem responses. After explant, the electrode surfaces were assessed, and cochleae examined histologically. Main results . When measured on bench-top before and after stimulation, Pt-Ir coated electrodes had significantly lower VT impedance (p ...

中文翻译：

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薄膜铂-铱合金电极涂层的电化学和生物学特性：一项长期的体内研究。

目的。若要评估电化学特性，生物反应和表面特性的耳蜗植入物上的电沉积铂铱（Pt-Ir）电极涂层在体内受到慢性刺激。方法。在植入物之前和之后以及在体内，台式测量电化学阻抗谱（EIS），电荷存储容量（CSC），电荷注入极限（CIL）和电压瞬态（VT）阻抗。将涂覆的Pt-Ir和未涂覆的Pt电极阵列植入正常听力大鼠的耳蜗中，并在正常临床范围内的水平刺激〜4 hd，5 d week -1达5周。使用电诱发的听觉脑干反应监测神经功能。外植后，评估电极表面，并组织学检查耳蜗。主要结果。