Background and Objective: The SOX2OT lcnRNA has been recognized as a positive regulator in the transcription regulation of the SOX2 gene. Recent studies have approved the dysregulation of SOX2OT lncRNA expression patterns in some common cancer types, including esophageal, lung, and breast cancer. The objective of the present study was to investigate the correlation between overexpression of SOX2OT lcnRNA and susceptibility to breast cancer.

Methods: SOX2OT lncRNA expression profiling in 15 breast cancer and normal tumour-adjacent breast tissue samples was performed by using qRT-PCR. To evaluate the diagnostic potential of the SOX2OT lncRNA, we performed ROC curve analyses.

Results: The expression of SOX2OT lncRNA in patients suffering from breast cancer revealed a significant overexpression in comparison with the healthy group (P<0.001). Significantly, the elevated circulating SOX2OT lncRNA was found specific to breast cancer and could differentiate breast cancer from controls with 100% of both sensitivity and specificity. Based on the Kaplan- Meier analysis, there was no significant correlation between SOX2OT lcnRNA expression and overall survival.

Conclusion: The results confirmed the association between breast cancer and higher SOX2OT lncRNA expression. According to the ROC curve results, SOX2OT lcnRNA could be a new measurable indicator of the breast cancer and a potential therapeutic target for breast cancer patients.

背景与目的：SOX2OT lcnRNA被认为是SOX2基因转录调控中的一种正调控因子。最近的研究已批准SOX2OT lncRNA表达模式在某些常见的癌症类型中失调，包括食道癌，肺癌和乳腺癌。本研究的目的是研究SOX2OT lcnRNA的过表达与乳腺癌易感性之间的相关性。

方法：采用qRT-PCR技术在15例乳腺癌和癌旁正常组织中进行SOX2OT lncRNA表达谱分析。为了评估SOX2OT lncRNA的诊断潜力，我们进行了ROC曲线分析。

结果：与健康组相比，乳腺癌患者中SOX2OT lncRNA的表达显示出明显的过表达（P <0.001）。重要的是，发现升高的循环SOX2OT lncRNA对乳腺癌具有特异性，并且可以100％的敏感性和特异性将乳腺癌与对照区分开。根据Kaplan-Meier分析，SOX2OT lcnRNA表达与总体存活率之间无显着相关性。

结论：该结果证实了乳腺癌与更高的SOX2OT lncRNA表达之间的关联。根据ROC曲线结果，SOX2OT lcnRNA可能是乳腺癌的一种新的可测量指标，也是乳腺癌患者的潜在治疗靶标。