Kidney tubules are lined with flow-sensing structures, yet information about the flow itself is not easily obtained. We aim to generate a multiscale biomechanical model for analyzing fluid flow and fluid-structure interactions within an elastic kidney tubule when the driving pressure is pulsatile. We developed a two-dimensional macroscopic mathematical model of a single fluid-filled tubule corresponding to a distal nephron segment and determined both flow dynamics and wall strains over a range of driving frequencies and wall compliances using finite-element analysis. The results presented here demonstrate good agreement with available analytical solutions and form a foundation for future inclusion of elastohydrodynamic coupling by neighboring tubules. Overall, we are interested in exploring the idea of dynamic pathology to better understand the progression of chronic kidney diseases such as Polycystic Kidney Disease.

中文翻译：

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通过理想化肾小管的脉动流：流体结构相互作用和动态病理。

肾小管内衬有流量感应结构，但不容易获得有关流量本身的信息。我们的目标是生成一个多尺度生物力学模型，用于在驱动压力为脉动时分析弹性肾小管内的流体流动和流固耦合。我们开发了对应于远端肾单位段的单个充满液体的小管的二维宏观数学模型，并使用有限元分析确定了一系列驱动频率和壁顺应性下的流动动力学和壁应变。此处显示的结果表明与可用的分析解决方案具有良好的一致性，并为未来包含相邻小管的弹性流体动力耦合奠定了基础。总体，