Prostate adenocarcinoma (PRAD) is one of the most frequently diagnosed cancer in males. Previous studies had demonstrated long non-coding RNAs (lncRNAs) played crucial roles in human cancers. In present study, we reported ten disease-free survival time related lncRNAs in PRAD, including RP11-468E2.5, GS1-393G12.13, CTD-2228K2.7, RP11-783K16.13, RP11-631N16.4, CTC-435M10.12, RP11-1109F11.5, RP11-228B15.4, RP11-496I9.1, and RP11-95O2.5. Higher expression of these lncRNAs significantly correlates to shorter DFS time in patients with PRAD. We next constructed lncRNAs regulating PPI networks in PRAD. Bioinformatics analysis revealed these DFS-related lncRNAs were associated with the regulation of cell cycle, glucose metabolic process, histone modification, and RNA splicing. AR and SPOP were identified to be involved in regulating these lncRNAs expression in PRAD. The prognostic value and molecular functions of these lnRNAs in human diseases remained largely unknown. We thought this study for the first time demonstrated that they could act as novel potential biomarkers for PRAD.

中文翻译：

---

鉴定10种不同表达的lncRNAs作为前列腺腺癌的预后生物标志物。

前列腺腺癌（PRAD）是男性中最常被诊断出的癌症之一。先前的研究表明，长期的非编码RNA（lncRNA）在人类癌症中起着至关重要的作用。在本研究中，我们报道了PRAD中十种与疾病无生存时间相关的lncRNA，包括RP11-468E2.5，GS1-393G12.13，CTD-2228K2.7，RP11-783K16.13，RP11-631N16.4，CTC- 435M10.12，RP11-1109F11.5，RP11-228B15.4，RP11-496I9.1和RP11-95O2.5。这些lncRNA的较高表达与PRAD患者的DFS时间缩短显着相关。接下来，我们在PRAD中构建了调控PPI网络的lncRNA。生物信息学分析表明，这些与DFS相关的lncRNA与细胞周期，葡萄糖代谢过程，组蛋白修饰和RNA剪接的调节有关。AR和SPOP被确定参与调节PRAD中这些lncRNA的表达。这些lnRNA在人类疾病中的预后价值和分子功能仍然未知。我们认为这项研究首次证明了它们可以作为PRAD的新型潜在生物标志物。