Objective

To determine the necessity for acid-washed containers for 24-h urine copper analysis.

Methods

Copper solutions, with concentrations relevant to clinical decision limits, were prepared by spiking both assay diluent and unknown urine samples with the copper calibrator. Samples were split between plain and acid-washed 24-h urine containers, and copper analysis was performed using inductively coupled mass spectrometry (ICP-MS).

Results

Measurement of copper in both spiked diluent and spiked urine samples showed minimal concentration bias between acid-washed and plain 24-h urine containers.

Conclusions

Acid-washed containers are not required for the measurement of copper in 24-h urine samples.

中文翻译：

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通过电感耦合等离子体质谱法评估24小时尿液容器中尿铜的测量。

目的

确定酸洗容器进行24小时尿铜分析的必要性。

方法

浓度与临床决策极限有关的铜溶液是通过用铜校准品加标测定稀释剂和未知尿液样品而制备的。将样品分为普通和酸洗的24小时尿液容器，并使用感应耦合质谱（ICP-MS）进行铜分析。

结果

加标稀释剂和加标尿液样品中铜的测量结果显示，酸洗和普通24小时尿液容器之间的浓度偏差最小。

结论

测量24小时尿液样品中的铜不需要酸洗容器。