An ASIC for a high frequency electrical impedance tomography (EIT) imaging system for prostate cancer screening is presented. The ASIC enables a small form-factor architecture, which ensures high signal-to-noise ratio (SNR) at MHz frequencies. The 4-channel ASIC was designed and fabricated in a standard CMOS 0.18- $\mu$ m technology and integrates a novel current driver for current stimulus, instrumentation amplifier to interface with the tissue, VGA to provide variable gain and ADC with SPI interface for digitization. A prototype miniaturized EIT system was built and it was evaluated using a model transrectal imaging probe immersed into a tank filled with saline and a metal inclusion that demonstrated the open-domain problem of imaging prostate cancer lesion. The system maintained an SNR between 66 and 76 dB over the frequency range of 500 Hz to 1 MHz. Also, it produced reconstructed EIT images that depicted the presence of the small metal inclusion that modeled a prostate cancer imaging application.

中文翻译：

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用于前列腺成像的1 MHz微型电阻抗层析成像系统。

提出了一种用于前列腺癌筛查的高频电阻抗层析成像（EIT）成像系统的ASIC。ASIC支持小尺寸的架构，可确保在MHz频率下具有较高的信噪比（SNR）。4通道ASIC是在标准CMOS 0.18- $ \ mu $ m技术并集成了用于电流刺激的新型电流驱动器，用于与组织连接的仪表放大器，用于提供可变增益的VGA和具有用于数字化的SPI接口的ADC。建立了原型微型化EIT系统，并使用模型的经直肠成像探头浸入装有盐水和金属夹杂物的罐中进行了评估，该探头证实了对前列腺癌病灶成像的开放域问题。该系统在500 Hz至1 MHz的频率范围内将SNR保持在66至76 dB之间。此外，它还产生了重建的EIT图像，该图像描述了模拟前列腺癌成像应用的小金属夹杂物的存在。