Four subtypes of breast cancer, luminal A, luminal B, basal-like, human epidermal growth factor receptor-enriched, have been identified based on gene expression profiles of human tumours. The goal of this study is to find whether the same groups' genes would exhibit different networks among the four subtypes. Differential expressed genes between each of the four subtypes and the normal samples were identified. The overlaps between the four groups of differentially expressed genes were used to construct regulations networks for each of the four subtypes. Univariate and multivariate Cox regressions were employed to test the genes in the four regulation networks. This study demonstrated that the common genes in four subtypes showed different regulation. Also, the hsa-miR-182 and decorin pair performs different functions among the four subtypes of breast cancer. The result indicated that heterogeneity of breast cancer is not only reflected in the different expression patterns among different genes, but also in the different regulatory networks of the same group of genes.

中文翻译：

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乳腺癌四种亚型中特定 microRNA-信使 RNA 调节对的鉴定。

根据人类肿瘤的基因表达谱，已鉴定出乳腺癌的四种亚型：管腔 A、管腔 B、基底样、富含人表皮生长因子受体的乳腺癌。这项研究的目的是找出同一群​​体的基因是否会在四种亚型中表现出不同的网络。鉴定了四种亚型与正常样本之间的差异表达基因。四组差异表达基因之间的重叠用于构建四种亚型中每一种的调控网络。采用单变量和多变量 Cox 回归来测试四个调控网络中的基因。这项研究表明，四种亚型的共同基因表现出不同的调控。此外，hsa-miR-182 和核心蛋白聚糖对在乳腺癌的四种亚型中发挥不同的功能。结果表明，乳腺癌的异质性不仅体现在不同基因之间的表达模式不同，而且还体现在同一组基因的不同调控网络上。