Thyroid cancer is among the most common type of head and neck cancer; diet, age, gender and environmental factors play vital roles in its malignancy. The present study was carried out to assess the imbalances in the contents of trace metals due to onset and progression of thyroid cancer. Scalp hair was used as matrix for the evaluation of toxic and trace metals. Quantification of the metals was done through atomic absorption spectrometry. In comparison with healthy subjects, the thyroid cancer patients revealed significantly higher median levels of Mn (71%), Co (64%), Cr (55%), K (49%), Fe (45%), Mg (42%), Pb (36%), Na (30%), and Ni (26%), while the median level of Zn was considerably lower in the patients. The correlation coefficients among the metals in the patients demonstrated significantly different communal relationships compared with the healthy counterparts. Multivariate methods exhibited noticeably dissimilar apportionment among the metals in the patients than the controls. Significant disparities in the metal levels were also noticed for various types (anaplastic thyroid cancer, follicular thyroid cancer, papillary thyroid cancer, and medullary thyroid cancer) as well as stages (I, II, III, and IV) among the thyroid cancer patients. Majority of the metals revealed perceptible disparities in their contents based on gender, habitat, dietary habits, and smoking habits of the patients and controls. Overall, the study showed significantly divergent distribution and associations of the essential and toxic metal levels in the scalp hair of the patients in comparison with the levels in controls.

中文翻译：

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与健康供体相比，甲状腺癌患者头皮头发中必需和有毒金属失衡的研究。

甲状腺癌是最常见的头颈癌之一。饮食、年龄、性别和环境因素在其恶性程度中起着至关重要的作用。本研究旨在评估由于甲状腺癌的发生和进展导致的微量金属含量的不平衡。头皮毛发被用作评估有毒和痕量金属的基质。通过原子吸收光谱法对金属进行定量。与健康受试者相比，甲状腺癌患者的锰 (71%)、钴 (64%)、铬 (55%)、钾 (49%)、铁 (45%)、镁 (42%) 的中位数水平显着更高)、Pb (36%)、Na (30%) 和 Ni (26%)，而患者中 Zn 的中位水平要低得多。与健康人相比，患者体内金属之间的相关系数表现出显着不同的公共关系。与对照组相比，多变量方法在患者体内的金属中表现出明显不同的分配。不同类型（未分化甲状腺癌、滤泡性甲状腺癌、乳头状甲状腺癌和甲状腺髓样癌）以及分期（I、II、III 和 IV）的甲状腺癌患者的金属水平也存在显着差异。根据患者和对照组的性别、栖息地、饮食习惯和吸烟习惯，大多数金属的含量存在明显差异。全面的，