A novel polymer (PEG2000-carborane), self-assembling into spherical vesicles (boron-containing vesicles, BCVs), could be quickly taken up by tumor cells and had an enhance stability in the bloodstream in previous study. To have more comprehensive understanding of BCVs, endocytic mechanism and cytotoxicity assessment were conducted. The results showed that BCVs were taken up in the intact form with cholesterol-dependent pathway during endocytosis, and BCVs exhibited nearly no cytotoxicity. BCVs could accumulate within tumors for at least 24 h. The data would provide reference information and guidance for BCVs' multifunctional application serving as a boron delivery agent for boron neutron capture therapy (BNCT), a hydrophilic and/or hydrophobic drug carrier and a diagnostic imaging fluorescent probe.

中文翻译：

---

含硼囊泡的内吞机理和细胞毒性。

自组装成球形囊泡（含硼囊泡，BCV）的新型聚合物（PEG2000-碳硼烷）可以被肿瘤细胞迅速吸收，并在先前的研究中具有增强的血流稳定性。为了更全面地了解BCV，进行了内吞机制和细胞毒性评估。结果表明，在胞吞过程中，BCV以完整的形式被胆固醇依赖性途径吸收，并且BCV几乎没有细胞毒性。BCV可能在肿瘤内累积至少24 h。该数据将为BCV的多功能应用提供参考信息和指导，该功能可用作硼中子俘获疗法（BNCT）的硼输送剂，亲水和/或疏水药物载体以及诊断成像荧光探针。