The main objective of this study was to develop an appropriate interpenetrating polymer network (IPN) particulate system from water-soluble polymers such as sodium alginate (NaAlg), poly (vinyl alcohol) (PVA) and methyl cellulose (MC) for the controlled release of flurbiprofen (FBP), a non-steroidal anti-inflammatory drug. Therefore, polymeric IPN beads containing FBP were prepared by crosslinking with glutaraldehyde (GA) as the crosslinking agent and by varying experimental variables such as polymer ratio, crosslinking time and drug/polymer ratio. Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were used to characterize the IPN beads. They were also evaluated with bead diameter, equilibrium swelling degrees, entrapment efficiencies and release profiles. It was observed that the release of FBP from beads was influenced by variables such as NaAlg amount in polymer matrix, crosslinking time and FBP/polymer ratio, and release mechanism of FBP from IPN beads followed non-Fickian transport. As a result of the studies, the highest drug release at the end of 6 h was observed in IPN beads with NaAlg/PVA/MC ratio of 4/1/1, FBP/polymer ratio of 1/4 and crosslinking time of 15 and 30 min.

本研究的主要目的是从水溶性聚合物如海藻酸钠 (NaAlg)、聚乙烯醇 (PVA) 和甲基纤维素 (MC) 中开发合适的互穿聚合物网络 (IPN) 颗粒系统，用于控释氟比洛芬 (FBP)，一种非甾体抗炎药。因此，通过用戊二醛 (GA) 作为交联剂和改变实验变量（如聚合物比例、交联时间和药物/聚合物比例）来制备含有 FBP 的聚合物 IPN 珠。傅里叶变换红外 (FTIR) 光谱、差示扫描量热法 (DSC) 和扫描电子显微镜 (SEM) 用于表征 IPN 珠。还评估了它们的珠直径、平衡溶胀度、包封效率和释放曲线。据观察，FBP 从珠子中的释放受变量的影响，例如聚合物基质中的 NaAlg 量、交联时间和 FBP/聚合物比率，以及 FBP 从 IPN 珠子中的释放机制遵循非 Fickian 传输。研究结果表明，在 NaAlg/PVA/MC 比率为 4/1/1、FBP/聚合物比率为 1/4 和交联时间为 15 和30分钟。