The spindle constitutes the cellular machinery that enables the segregation of the chromosomes during eukaryotic cell division. The microtubules that form this fascinating and complex genome distribution system emanate from specialized structures located at both its poles and known as microtubule-organizing centers (MTOCs). Beyond their structural function, the spindle MTOCs play fundamental roles in cell cycle control, the activation and functionality of the mitotic checkpoints and during cellular aging. This review highlights the pivotal importance of spindle-associated MTOCs in multiple cellular processes and their central role as key regulatory hubs where diverse intracellular signals are integrated and coordinated to ensure the successful completion of cell division and the maintenance of the replicative lifespan.

纺锤体构成了细胞机器，能够在真核细胞分裂过程中分离染色体。形成这个迷人而复杂的基因组分布系统的微管来自位于其两极的特殊结构，称为微管组织中心 (MTOC)。除了其结构功能之外，纺锤体 MTOC 在细胞周期控制、有丝分裂检查点的激活和功能以及细胞衰老过程中发挥着重要作用。这篇综述强调了纺锤体相关 MTOC 在多个细胞过程中的关键重要性及其作为关键调节枢纽的核心作用，在这些枢纽中整合和协调了多种细胞内信号，以确保细胞分裂的成功完成和复制寿命的维持。