Ovarian cancer (OC) is one of gynecological malignancies that seriously affects women's health. Mounting evidence demonstrated that long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and messenger RNAs (mRNAs) play important roles in various biological processes related to the pathogenesis of OC. This research aimed to investigate the regulatory mechanism of lncRNA SCAMP1/miR-137/CXCL12 (C-X-C motif chemokine ligand 12) axis on OC progression. In this study, we found that SCAMP1 was highly expressed in OC cells, which promoted OC cell invasion and angiogenesis. In addition, our research confirmed that SCAMP1 could bind with miR-137, and SCAMP1 sponged miR-137 to accelerate the progression of OC. We also observed that CXCL12 was a downstream target gene for miR-137, and miR-137 targeted CXCL12 to participate in the regulation of OC. Finally, through TCGA database, we found that SCAMP1 (or CXCL12) was upregulated as well as miR-137 was downregulated in OC tissues, and high (or low) level of them was associated with poor prognosis. miR-137 expression was negatively correlated with SCAMP1 (or CXCL12) expression, and SCAMP1 expression was positively correlated with CXCL12 expression in OC. In summary, our study clarified the role of SCAMP1/miR-137/CXCL12 axis in OC, and this finding may provide a potential therapeutic target of OC.

中文翻译：

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长非编码RNA SCAMP1靶向miR-137 / CXCL12轴，以促进卵巢癌中的细胞侵袭和血管生成。

卵巢癌（OC）是严重影响女性健康的妇科恶性肿瘤之一。越来越多的证据表明，长的非编码RNA（lncRNA），微小RNA（miRNA）和信使RNA（mRNA）在与OC发病机理有关的各种生物学过程中都起着重要作用。这项研究旨在调查lncRNA SCAMP1 / miR-137 / CXCL12（CXC基序趋化因子配体12）轴对OC进展的调控机制。在这项研究中，我们发现SCAMP1在OC细胞中高表达，从而促进OC细胞的侵袭和血管生成。此外，我们的研究证实SCAMP1可以与miR-137结合，而SCAMP1可以使miR-137结合以加速OC的进程。我们还观察到CXCL12是miR-137的下游靶基因，而miR-137则靶向CXCL12参与OC的调控。最后，通过TCGA数据库，我们发现OC组织中的SCAMP1（或CXCL12）被上调，而miR-137被下调，它们的高（或低）水平与不良预后相关。在OC中，miR-137表达与SCAMP1（或CXCL12）表达负相关，而SCAMP1表达与CXCL12表达正相关。总之，我们的研究阐明了SCAMP1 / miR-137 / CXCL12轴在OC中的作用，这一发现可能为OC提供潜在的治疗靶点。