Background: Hyperuricemia occurs frequently in patients with continuous ambulatory peritoneal dialysis (CAPD). This study aimed to evaluate the impact of serum uric acid (UA) over time on residual renal function (RRF) loss in a cohort of patients with CAPD.Methods: A total of 201 patients who started CAPD therapy between January 1, 2008 and April 30, 2016 were included in this single-center, retrospective cohort study. All patients were followed up until December 31, 2016. The median follow-up time was 23.43 ± 16.60 months. RRF loss was represented as the time to anuria.Results: Eighty-six patients developed anuria within 5 years. Multivariate Cox regression analysis showed that time-averaged serum UA and peritonitis were independent risk factors for RRF loss, while weekly Kt/V urea was a protective factor. Cox proportional hazard regression models showed that both patients with time-averaged uric acid (TA-UA) < 6.77 mg/dL [hazard ratio (HR) = 1.165, 95% confidence interval (CI) 1.054-1.387; p < 0.05] and those with TA-UA≥ 7.64 mg/dL (HR = 1.184, 95% CI 1.045-2.114; p < 0.05) had a higher risk of RRF than those with TA-UA in the range of 6.77-7.64 mg/dL. Penalized spline smoothing also showed a U-shaped relationship between continuous UA and RRF loss.Conclusion: The present study demonstrated that both high and low serum UA over time were associated with RRF loss in patients with CAPD.

中文翻译：

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纵向分析腹膜透析患者血清尿酸与残余肾功能丧失之间的关系。

背景：持续性非卧床腹膜透析（CAPD）患者经常发生高尿酸血症。这项研究旨在评估随时间推移的血清尿酸（UA）对一组CAPD患者的残余肾功能（RRF）丧失的影响。方法：2008年1月1日至4月间开始进行CAPD治疗的201例患者这项单中心回顾性队列研究纳入了2016年30月30日的研究。所有患者均获随访，直至2016年12月31日。中位随访时间为23.43±16.60个月。结果：RRF丧失是无尿时间。结果：86名患者在5年内出现无尿。多元Cox回归分析显示，平均时间的血清UA和腹膜炎是RRF丢失的独立危险因素，而每周Kt / V尿素是保护因素。Cox比例风险回归模型显示，两名患者的平均尿酸时间（TA-UA）<6.77 mg / dL [风险比（HR）= 1.165，95％置信区间（CI）为1.054-1.387。p <0.05]和TA-UA≥7.64 mg / dL（HR = 1.184，95％CI 1.045-2.114; p <0.05）的RRF风险高于TA-UA的6.77-7.64毫克/分升 罚样条平滑处理也显示连续UA和RRF丢失之间呈U形关系。结论：本研究表明，CAPD患者随时间推移的高和低血清UA均与RRF丢失有关。05）在6.77-7.64 mg / dL范围内，比具有TA-UA的RRF风险更高。罚样条平滑处理也显示连续UA和RRF丢失之间呈U型关系。结论：本研究表明，CAPD患者随时间推移的高和低血清UA与RRF丢失有关。05）在6.77-7.64 mg / dL范围内，比具有TA-UA的RRF风险更高。罚样条平滑处理也显示连续UA和RRF丢失之间呈U型关系。结论：本研究表明，CAPD患者随时间推移的高和低血清UA与RRF丢失有关。