Understanding and targeting of GPCRs remain a critical aspect of airway pharmacology and therapeutics for diseases such as asthma or COPD. Most attention has been on the large Class A GPCRs towards improved bronchodilation and blunting of remodeling. Better known in the central or peripheral nervous system, there is increasing evidence that Class C GPCRs which include metabotropic glutamate and GABA receptors, the calcium sensing receptor, sweet/umami taste receptors and a number of orphan receptors, can contribute to airway structure and function. In this review, we will summarize current state of knowledge regarding the pharmacology of Class C GPCRs, their expression and potential functions in the airways, and the application of pharmacological agents targeting this group in the context of airway diseases.

中文翻译：

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气道中的 C 类 GPCR。

GPCR 的理解和靶向仍然是气道药理学和哮喘或 COPD 等疾病治疗的一个重要方面。大多数注意力都集中在大型 A 类 GPCR 上，以改善支气管扩张和重塑钝化。在中枢或周围神经系统中更为人所知，越来越多的证据表明，包括代谢型谷氨酸和 GABA 受体、钙敏感受体、甜味/鲜味受体和许多孤儿受体的 C 类 GPCR 可以促进气道结构和功能. 在这篇综述中，我们将总结有关 C 类 GPCR 的药理学、它们在气道中的表达和潜在功能以及针对该组的药物在气道疾病中的应用的知识现状。