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Human mast cells exhibit an individualized pattern of antimicrobial responses.
Immunity, Inflammation and Disease ( IF 2.493 ) Pub Date : 2020-03-28 , DOI: 10.1002/iid3.295
Karen M Garcia-Rodriguez 1, 2 , Rajia Bahri 1 , Clara Sattentau 1 , Ian S Roberts 1 , Anu Goenka 1, 3 , Silvia Bulfone-Paus 1
Affiliation  

Mast cells (MCs) are tissue‐resident immune cells implicated in antibacterial responses. These include chemokine secretion, degranulation, and the release of mast cell‐extracellular traps, which are primarily dependent on reactive oxygen species (ROS) production. Our study investigated whether human mast cells (hMCs) develop individual response patterns to bacteria located at different tissue sites: Escherichia coli (gut commensal), Listeria monocytogenes (foodborne intracellular pathogen), Staphylococcus aureus (skin commensal and opportunistic pathogen), and Streptococcus pneumoniae (upper respiratory tract commensal and lung pathogen).

中文翻译:

人肥大细胞表现出抗微生物反应的个性化模式。

肥大细胞(MCs)是组织驻留的免疫细胞,与抗菌反应有关。这些包括趋化因子分泌,脱粒和肥​​大细胞-细胞外陷阱的释放,这主要取决于活性氧(ROS)的产生。我们的研究调查了人类肥大细胞(hMCs)是否对位于不同组织部位的细菌产生了单独的反应模式:大肠杆菌(肠道共生),单核细胞增生李斯特菌(食源性细胞内病原体),金黄色葡萄球菌(皮肤共生和机会性病原体)和肺炎链球菌(上呼吸道共病和肺部病原体)。
更新日期:2020-03-28
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