We previously reported that fibroblast growth factor 23 (FGF23)‐klotho signaling plays a role in B cell immunity. Despite high serum levels of FGF23, a decline in immunity is frequently observed in patients on hemodialysis (HD); thus, abnormalities in the FGF23‐klotho signaling pathway in immune cells may occur in these patients.

中文翻译：

---

在尿毒症患者中会发生过度的ADAM17激活，并可能导致其免疫功能低下。

我们以前曾报道过成纤维细胞生长因子23（FGF23）-klotho信号在B细胞免疫中起作用。尽管血清中的FGF23含量很高，但在血液透析（HD）患者中经常观察到免疫力下降。因此，这些患者的免疫细胞中的FGF23-klotho信号通路可能异常。