Drug hypersensitivity is one of the most frequent causes of anaphylaxis, particularly in adults and in hospitalized patients. Drug-induced anaphylaxis (DIA) is also associated with more severe outcomes than other anaphylaxis triggers, and drugs are responsible for the majority of deaths due to anaphylaxis. We here review the current knowledge on the incidence, prevalence, drugs involved, mortality, and mortality risk factors for DIA. The incidence of both anaphylaxis and DIA seems to be increasing worldwide. Antibiotics and analgesics are the most frequently reported triggers of DIA. However, the importance of other drug groups should be taken into account, especially in particular settings (e.g., peri-operative and oncology). The identification of risk factors, geographical variables, and drugs associated with higher risk for DIA may improve the outcomes of this entity.
Int Arch Allergy Immunol

中文翻译：

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药物引起的过敏反应：流行病学和危险因素的更新。

药物超敏反应是引起过敏反应的最常见原因之一，尤其是在成年人和住院患者中。与其他过敏反应触发因素相比，药物诱导的过敏反应（DIA）还具有更严重的后果，并且药物是造成过敏反应死亡的主要原因。我们在这里回顾有关DIA的发生率，患病率，所涉及的药物，死亡率和死亡率危险因素的最新知识。全球范围内，过敏反应和DIA的发病率似乎都在增加。抗生素和止痛药是DIA最常报告的诱因。但是，应考虑其他药物组的重要性，尤其是在特定情况下（例如围手术期和肿瘤科）。识别风险因素，地理变量，
Int Arch过敏免疫