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Retinal Ganglion Cell Axon Wiring Establishing the Binocular Circuit.
Annual Review of Vision Science ( IF 6 ) Pub Date : 2020-09-16 , DOI: 10.1146/annurev-vision-091517-034306
Carol Mason 1, 2, 3, 4 , Nefeli Slavi 4
Affiliation  

Binocular vision depends on retinal ganglion cell (RGC) axon projection either to the same side or to the opposite side of the brain. In this article, we review the molecular mechanisms for decussation of RGC axons, with a focus on axon guidance signaling at the optic chiasm and ipsi- and contralateral axon organization in the optic tract prior to and during targeting. The spatial and temporal features of RGC neurogenesis that give rise to ipsilateral and contralateral identity are described. The albino visual system is highlighted as an apt comparative model for understanding RGC decussation, as albinos have a reduced ipsilateral projection and altered RGC neurogenesis associated with perturbed melanogenesis in the retinal pigment epithelium. Understanding the steps for RGC specification into ipsi- and contralateral subtypes will facilitate differentiation of stem cells into RGCs with proper navigational abilities for effective axon regeneration and correct targeting of higher-order visual centers.

中文翻译:


建立双眼电路的视网膜神经节细胞轴突接线。

双眼视觉取决于视网膜神经节细胞 (RGC) 轴突投射到大脑的同一侧或另一侧。在本文中,我们回顾了 RGC 轴突讨论的分子机制,重点是视交叉处的轴突引导信号传导以及在靶向之前和期间视束中的同侧和对侧轴突组织。描述了引起同侧和对侧身份的 RGC 神经发生的空间和时间特征。白化病视觉系统被强调为理解 RGC 交叉的一个恰当的比较模型,因为白化病患者的同侧投射减少,并且与视网膜色素上皮细胞中受干扰的黑色素生成相关的 RGC 神经发生改变。

更新日期:2020-09-18
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