Increasing evidence suggested that long noncoding RNAs (lncRNAs) variants may be involved in the progression of various cancers. However, the association of the lncRNAs polymorphisms with the risk for esophagogastric junction adenocarcinoma (EGJA) is still unknown. In this case–control study, we selected two cancer-related lncRNAs polymorphisms (rs944289 C > T and rs7990916 C>T), and recruited a total of 1063 EGJA patients and 1677 noncancer controls to determine whether the lncRNAs rs944289 C > T and rs7990916 C > T polymorphisms could influence EGJA susceptibility and lymph node status. And SNPscan™ genotyping assay was applied to test the genotypes of the mentioned two variants. We found no statistically significant differences in the distribution of lncRNAs rs944289 C > T and rs7990916 C > T polymorphisms between EGJA patients and healthy controls. Similar negative findings were also revealed in the correlation of those polymorphisms with different lymph node status. However, after adjustment by multiple environmental factors, including gender, age, drinking, and smoking consumption, the stratified analyses showed that the lncRNAs rs944289 C > T variant was significantly related with the risk of EGJA in <60 years populations [CT vs. CC: adjusted odds ratio (OR) = 0.75, 95% confidence interval (CI) = 0.58–0.98, p = 0.032] and ever smoking populations (CT/CC vs. TT: adjusted OR = 1.65, 95% CI = 1.11–2.46, p = 0.013). In short, this population-based study highlights that lncRNAs rs944289 C > T polymorphism may be associated with genetic susceptibility to EGJA in the <60 years and ever smoking populations.

中文翻译：

---

长非编码RNA多态性与食管胃交界处腺癌风险的关联：对1063例病例和1677例对照的三中心研究。

越来越多的证据表明，长的非编码RNA（lncRNA）变体可能与各种癌症的进展有关。然而，lncRNAs多态性与食管胃交界处腺癌（EGJA）的风险之间的关联仍然未知。在本病例对照研究中，我们选择了两种与癌症相关的lncRNA多态性（rs944289 C> T和rs7990916 C> T），并共招募了1063名EGJA患者和1677名非癌对照，以确定是否为lncRNArs944289 C> T和rs7990916 C> T多态性可能影响EGJA易感性和淋巴结状态。然后使用SNPscan™基因分型分析法来测试上述两个变体的基因型。我们发现EGJA患者和健康对照组的lncRNA rs944289 C> T和rs7990916 C> T多态性分布没有统计学显着差异。这些多态性与不同淋巴结状态的相关性也揭示了相似的阴性结果。但是，经过多种环境因素（包括性别，年龄，饮酒和吸烟量）的调整后，分层分析显示，lncRNAsrs944289 C> T变异与<60岁人群的EGJA风险显着相关[CT vs. CC：调整后的优势比（OR）= 0.75，95％置信区间（CI）= 0.58–0.98，p  = 0.032]和曾经吸烟的人群（CT / CC与TT：调整后OR = 1.65，95％CI = 1.11–2.46，p  = 0.013）。简而言之，这项基于人群的研究突显了lncRNA rs944289 C> T多态性可能与<60岁及以后吸烟人群对EGJA的遗传易感性有关。