Abstract

Soy consumption and its components, including its protein, are related to the beneficial effects of the lipid profile, decreased insulin resistance and glycaemia. However, the safety of the consumption of products containing phytoestrogens in critical stages of development has been questioned, since they may be associated with endocrine-metabolic dysfunctions in adult life. The purpose is to evaluate the effects of maternal dietary soy protein isolate (SPI) during lactation on the breast milk composition, body composition, lipid and glycaemic profiles, and thyroid hormones of dams and offspring at weaning (21 days) and in adulthood (150 days). Lactating rats were divided into casein control (C) and SPI diet groups. At 150 days, the SPI offspring presented lower body protein mass and total mineral content, higher serum FT4, insulin, TC and TG. Maternal consumption of SPI during lactation programmes the progeny to higher metabolic risk profile.

摘要

大豆的消费及其成分（包括蛋白质）与脂质分布，降低的胰岛素抵抗和血糖的有益作用有关。然而，在植物的关键发展阶段消费含有植物雌激素的产品的安全性受到了质疑，因为它们可能与成年后的内分泌代谢功能障碍有关。目的是评估哺乳期间母体日粮大豆分离蛋白（SPI）对断奶（21天）和成年后（150天）母乳和大坝及后代的母乳成分，身体成分，脂质和血糖谱以及甲状腺激素的影响天）。泌乳大鼠分为酪蛋白对照组（C）和SPI饮食组。在150天时，SPI后代的身体蛋白质质量和总矿物质含量较低，血清FT4，胰岛素，TC和TG较高。