Migrating cells need to coordinate extension and retraction of their protrusions to avoid fragmenting. Kopf et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201907154) demonstrate that microtubules help to maintain cell coherence during amoeboid migration by controlling actomyosin contractility in retracting protrusions.

中文翻译：

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微管保持大细胞的形状

迁移细胞需要协调其突出物的伸展和缩回，以避免破碎。科普夫等人。(2020. J. Cell Biol.https://doi.org/10.1083/jcb.201907154) 证明微管通过控制缩回突起时的肌动球蛋白收缩性，有助于在变形虫迁移过程中维持细胞的一致性。