当前位置: X-MOL 学术J. Reprod. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The correlation of thyroid autoimmunity and peripheral and uterine immune status in women with recurrent miscarriage.
Journal of Reproductive Immunology ( IF 3.4 ) Pub Date : 2020-03-10 , DOI: 10.1016/j.jri.2020.103118
Su Liu 1 , Fen Xu 1 , Hongxia Wei 1 , Chunyu Huang 1 , Xian Chen 1 , Ruochun Lian 1 , Yong Zeng 1
Affiliation  

PROBLEM Thyroid autoimmunity (TAI), which is the most prevalent cause of thyroid dysfunction in women of reproductive age, is associated with increased risk of miscarriages and adverse pregnancy outcomes. However, the exact pathophysiology of TAI is still unknown. We aim at investigating the relationship between TAI and the peripheral and uterine immune markers in women with recurrent miscarriage (RM). METHOD OF STUDY Peripheral blood and endometrial tissue samples were collected during mid-luteal phase of 242 RM women to evaluate the prevalence of TAI, the thyroid function, the percentages of peripheral blood and endometrial lymphocytes, the levels of peripheral blood T helper 1 (Th1) cytokine and natural killer (NK) cell cytotoxicity. RESULTS There was no relationship between TAI and peripheral immune parameters. However, the percentage of endometrial Regulatory T (Treg) cells was significantly higher in RM women who were thyroid antibody positive than in those who were antibody negative (p < 0.05). CONCLUSION Thyroid antibody positivity seems to be part of a more generalized immune dysfunction. The increased endometrial Treg cells in RM patients with TAI may ameliorate coincidental TAI during pregnancy by linked suppression and prevent the over-reactive status of the immune system.

中文翻译:

复发性流产妇女甲状腺自身免疫与外周和子宫免疫状态的相关性。

问题 甲状腺自身免疫 (TAI) 是育龄妇女甲状腺功能障碍的最常见原因,与流产和不良妊娠结局的风险增加有关。然而,TAI 的确切病理生理学仍然未知。我们旨在研究 TAI 与复发性流产 (RM) 妇女的外周和子宫免疫标志物之间的关系。研究方法 收集 242 名 RM 女性在黄体中期的外周血和子宫内膜组织样本,以评估 TAI 的患病率、甲状腺功能、外周血和子宫内膜淋巴细胞百分比、外周血 T 辅助因子 1(Th1 ) 细胞因子和自然杀伤 (NK) 细胞的细胞毒性。结果 TAI 与外周免疫参数之间没有关系。然而,甲状腺抗体阳性的 RM 女性子宫内膜调节性 T (Treg) 细胞百分比显着高于抗体阴性的女性(p < 0.05)。结论 甲状腺抗体阳性似乎是更广泛的免疫功能障碍的一部分。患有 TAI 的 RM 患者增加的子宫内膜 Treg 细胞可能通过相关抑制来改善妊娠期间的巧合 TAI,并防止免疫系统的过度反应状态。
更新日期:2020-03-10
down
wechat
bug