Worldwide, many emerging porcine parvoviruses (PPVs) have been linked to porcine circovirus‐2 (PCV2) associated disease (PCVAD), which includes post‐weaning multi‐systemic wasting syndrome (PMWS), PCV2‐related reproductive failure (PCV2‐RF), as well as other syndromes. To determine the DNA prevalence of PPVs and their relationship with PMWS and PCV2‐RF in Mexico, 170 formalin‐fixed paraffin‐embedded tissues were selected from archival collections to detect PPVs using a nested polymerase chain reaction. The tissues were composed of 50 PMWS cases, 20 age‐matched tissues from healthy pigs, 56 PCV2‐related reproductive failure (PCV2⁺‐RF) cases, and 44 PCV2^‐‐RF cases. Overall, PPV2 and PPV6 were the most prevalent species (90.0% and 74.7%, respectively). In 8–11 week old pigs, the highest prevalence was for PPV6 and PPV3. Concerning reproductive failure, the PCV2‐affected farms had a significantly higher prevalence for PPV6 (61.6%) and PPV5 (36.4%) than the PCV2‐unaffected farms (35.0% and 5.0%, respectively). The concurrent infection rate was high, being significant for PPV2/PPV4 and PPV1/PPV5 within the PMWS cases and for PPV6/PPV5 among the PCV2⁺‐RF tissues. PPV5 showed a significant relationship with PMWS, whereas PPV5 and PPV6 were significant for PCVAD. The prevalence and coinfection rate of PPVs in Mexico were markedly higher than that described in other countries, denoting that PPV5 and PPV6 might have a potential role in PCVAD in Mexico. It is concluded that it is likely that the density population of pigs in Mexico is contributing to high PPV inter‐species and PCV2 coinfections which might lead to a different pathogenic outcome.

中文翻译：

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墨西哥猪细小病毒的DNA流行及其与猪圆环病毒相关疾病的关系的回顾性研究。

在全球范围内，许多新兴的猪细小病毒（PPV）与猪圆环病毒2（PCV2）相关疾病（PCVAD）相关，包括断奶后多系统消耗综合症（PMWS），与PCV2相关的生殖衰竭（PCV2-RF） ，以及其他综合症。为了确定PPV的DNA流行及其在墨西哥与PMWS和PCV2-RF的关系，从档案馆中选择了170个福尔马林固定石蜡包埋的组织，使用巢式聚合酶链反应检测PPV。将组织由50 PMWS的情况下，从健康猪20年龄匹配的组织中，56 PCV2相关繁殖障碍（PCV2 ⁺ -RF）的情况下，和44 PCV2 ^-‐RF案例。总体而言，PPV2和PPV6是最流行的物种（分别为90.0％和74.7％）。在8-11周龄的猪中，PPV6和PPV3的患病率最高。关于生殖衰竭，受PCV2影响的农场的PPV6（61.6％）和PPV5（36.4％）的患病率比未受PCV2影响的农场（分别为35.0％和5.0％）高。并发感染率很高，在PMWS病例中PPV2 / PPV4和PPV1 / PPV5显着，在PCV2 ^+中PPV6 / PPV5显着‐RF组织。PPV5与PMWS呈显着相关性，而PPV5和PPV6对PCVAD则具有显着性。墨西哥PPV的患病率和合并感染率明显高于其他国家，这表明PPV5和PPV6在墨西哥的PCVAD中可能具有潜在作用。结论是，墨西哥猪的种群密度很可能导致高PPV种间和PCV2合并感染，这可能导致不同的致病结果。