Alzheimer Disease & Associated Disorders ( IF 2.1 ) Pub Date : 2020-07-01 , DOI: 10.1097/wad.0000000000000340 Juri Kitamura 1 , Michiaki Nagai 2 , Hiroki Ueno 1 , Tomohiko Ohshita 3 , Mai Kikumoto 3 , Megumi Toko 3 , Masaya Kato 2 , Keigo Dote 3 , Hiroshi Yamashita 3 , Kazuomi Kario 4
Recent findings indicate that the human cardiovascular system is regulated by a cortical network comprised of the insular cortex (Ic), anterior cingulate gyrus, and amygdala which is necessary for the regulation of the central autonomic network system. Alzheimer disease (AD) affects the Ic at a preclinical stage. The pathology of AD at the Ic is suggested to predispose the cardiovascular system to detrimental changes such as increased blood pressure variability (BPV). In this review article, we focus on the physiology of the Ic in the relationship between the central autonomic network and BPV. We provide a summary of the published evidence regarding the relationship between Ic damage and exaggerated BPV in the context of AD pathology.
中文翻译:
岛状皮层,阿尔茨海默氏病病理及其对血压变异性的影响。
最近的发现表明,人的心血管系统由皮层网络调节,该皮层网络由岛状皮质(Ic),前扣带回和杏仁核组成,这是调节中央自主神经系统所必需的。阿尔茨海默氏病(AD)在临床前阶段会影响Ic。建议在Ic处进行AD病理检查,以使心血管系统易于发生有害变化,例如血压变异性(BPV)增加。在这篇评论文章中,我们将重点放在中央自主神经网络与BPV之间关系中的Ic生理上。我们提供了有关AD病理背景下Ic损伤与BPV夸大之间关系的已发表证据的摘要。