Escherichia coli sequence type (ST) 131 is considered a high-risk pandemic clone and frequently extended-spectrum β-lactamase (ESBL)-producing clone that is strongly associated with the global dissemination of CTX-M-15 type. The emergence of ST131 has become a public health threat because this clonal group typically exhibits multiple virulence factors and antimicrobial resistance. Therefore, this study aimed to analyze the literature published on the estimation of the prevalence of clone ST131 among E. coli strains isolated from patients with urinary tract infections in western Asia. A systematic search was carried out to identify eligible articles in the Web of Science, PubMed, Scopus, Embase, and Google Scholar electronic databases from January 2010 to December 2018. Next, 13 articles meeting the inclusion criteria were selected for data extraction and analysis by Comprehensive Meta-Analysis Software. The included studies were conducted in Iran, Jordan, Kuwait, Pakistan, Saudi Arabia, Turkey, and Yemen. In all studies, the pooled prevalence of ST131 was 24.6% (95% CI: 13.5%–40.4%) in wild type isolates, 42.7% (95% CI: 32.5%–53.5%) among ESBLs-producing isolates, and 64.8% (95% CI: 36%–85.5%) among multiple-drug resistant (MDR) isolates. Moreover, the prevalence of ST131 isolates carrying CTX-M-15 type was 68% (95% CI: 48.4%–82.8%). Our study indicated the high prevalence of broadly disseminated ST131 clone among MDR and ESBLs isolates in western Asia. Moreover, O25b was the predominant ST131 clone type, which was mostly associated with CTX-M-15 type.

中文翻译：

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导致西亚尿路感染的大肠杆菌 ST131 的出现：系统评价和荟萃分析。

大肠杆菌序列类型 (ST) 131 被认为是一种高风险的大流行克隆，并且经常产生超广谱 β-内酰胺酶 (ESBL) 克隆，与 CTX-M-15 类型的全球传播密切相关。ST131 的出现已成为公共卫生威胁，因为该克隆群通常表现出多种毒力因子和抗菌素耐药性。因此，本研究旨在分析已发表的有关估计大肠杆菌中克隆 ST131 流行率的文献。从西亚尿路感染患者中分离出的菌株。对2010年1月至2018年12月Web of Science、PubMed、Scopus、Embase和Google Scholar电子数据库中的符合条件的文章进行系统检索，筛选出符合纳入标准的13篇文章进行数据提取和分析。综合元分析软件。纳入的研究在伊朗、约旦、科威特、巴基斯坦、沙特阿拉伯、土耳其和也门进行。在所有研究中，ST131 的合并流行率在野生型分离株中为 24.6%（95% CI：13.5%–40.4%），在产 ESBLs 分离株中为 42.7%（95% CI：32.5%–53.5%），64.8% (95% CI: 36%–85.5%) 在多重耐药 (MDR) 分离株中。此外，携带 CTX-M-15 型的 ST131 分离株的流行率为 68%（95% CI：48.4%–82.8%）。我们的研究表明，在西亚的 MDR 和 ESBLs 分离株中广泛传播的 ST131 克隆的流行率很高。此外，O25b 是主要的 ST131 克隆类型，主要与 CTX-M-15 类型相关。