Halitosis is referred to as an unpleasant odor coming from the mouth. Recently, probiotics have been studied as an alternative prevention for halitosis. The aim of this study was to evaluate the effects of probiotic bacterium Weissella cibaria Chonnam Medical University (CMU)-containing tablets (1 × 10⁸ colony forming units [CFU]/g) on oral malodor. The randomized, double-blind, placebo-controlled trial was conducted in 92 healthy adults (20–39 years of age) with bad breath. All subjects were randomly assigned to a test (probiotic, n = 49) or control (placebo, n = 43) group after dental scaling and root planing. The tablets were taken once daily for 8 weeks. Measurements included an organoleptic test (OLT), volatile sulfur compounds (VSC), bad breath improvement (BBI) scores, and the oral colonization of W. cibaria CMU. This study also assessed safety variables of adverse reactions, vital signs, and the findings of hematology and blood chemistry. Most of the variables were measured at baseline, 4, and 8 weeks. Safety-related variables were measured at baseline and 8 weeks. At week 4, a significant decrease in OLT and VSC results was observed in the test group while BBI scores were significantly reduced at week 8 (P < .05). Statistically significant intergroup differences were observed for changes in W. cibaria number at weeks 4 and 8. No safety issues were encountered in either group. These results indicate that W. cibaria CMU tablets could be a safe and useful oral care product for controlling bad breath.

中文翻译：

---

通过包含Weissella cibaria CMU的片剂减少口臭：一项随机，双盲，安慰剂对照的研究。

口臭被认为是来自口腔的难闻气味。最近，已经研究了益生菌作为口臭的替代预防方法。这项研究的目的是评估含益生菌Weissella cibaria中南医科大学（CMU）的片剂（1×10 ⁸集落形成单位[CFU] / g）对口腔恶臭的作用。这项随机，双盲，安慰剂对照试验是针对92名口臭的健康成年人（20-39岁）进行的。将所有受试者随机分配至测试（益生菌，n  = 49）或对照组（安慰剂，n = 43）牙齿除鳞和根部平整后分组。每天服用一次，持续8周。测量包括感官测试（OLT），挥发性含硫化合物（VSC），口臭改善（BBI）评分和口岸W. cibaria CMU的定植。这项研究还评估了不良反应，生命体征以及血液学和血液化学发现的安全性变量。大多数变量在基线，第4和第8周测量。在基线和第8周测量与安全相关的变量。在第4周，测试组的OLT和VSC结果显着下降，而在第8周，BBI评分显着下降（P  <.05）。观察到W. cibaria的变化具有统计学意义的群体间差异第4周和第8周的数字。两组均未遇到安全问题。这些结果表明，W。cibaria CMU片剂可能是控制口臭的安全有效的口腔护理产品。