First Detection of a Circulating Recombinant Form of HIV-1 CRF01_AE/08_BC (CRF105_0108) with Drug-Resistant Mutations in Sichuan, China.,AIDS Research and Human Retroviruses

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First Detection of a Circulating Recombinant Form of HIV-1 CRF01_AE/08_BC (CRF105_0108) with Drug-Resistant Mutations in Sichuan, China.
AIDS Research and Human Retroviruses ( IF 1.5 ) Pub Date : 2020-07-02 , DOI: 10.1089/aid.2020.0034
Aobo Dong _{1,

2} , Lei Liu ₁ , Lin Xiao ₃ , Shu Liang ₄ , Kang Li ₁ , Jing Hu ₁ , Ruihua Kang ₁ , Jihong Xing ₅ , Chang Song ₁ , Jun Yin ₅ , Shuiling Qu ₆ , Yuhua Ruan ₁ , Yi Feng ₁ , Lingjie Liao ₁ , Yiming Shao ₁ , Hui Xing ₁

Affiliation

In this study, we identified a novel circulating recombinant form (CRF) of HIV (CRF105_0108) in a total of five patients with no obvious epidemiological linkage in Sichuan, China. Four strains were found in this study, and another strain (XC2014EU01) was reported in a previous study. The phylogenetic analysis of the five near full-length genomes showed that a CRF08_BC segment was inserted into the CRF01_AE backbone with one recombinant breakpoint in the pol region, which is the first HIV-1 CRF of CRF01_AE and CRF08_BC. Three genetic sequences had drug-resistant mutations, E138Q and V179D, indicating that there were low resistance levels to efavirenz (EFV) and nevirapine (NVP) in Liangshan Yi Autonomous Prefecture. CRF105_0108 increases the diversity and complexity of the prevalent HIV-1 CRFs in Sichuan. Simultaneously, drug-resistant mutations in this CRF may influence the efficacy of highly active antiretroviral treatments (ARTs) in Liangshan Yi Autonomous Prefecture.

更新日期：2020-07-03

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