There has been increasing interest in identifying factors to predict subjective well-being in the emerging field of positive psychology over the past two decades. Dispositional hope, which reflects one’s goal-directed tendencies, including both pathway thinking (planning to meet goals) and agency thinking (goal-directed determination), has emerged as a stable predictor for subjective well-being. However, the neurobiological substrates of dispositional hope and the brain-hope mechanism for predicting subjective well-being remain unclear. Here, we examined these issues in 231 high school graduates within the same grade by estimating cortical gray matter volume (GMV) utilizing a voxel-based morphometry method based on structural magnetic resonance imaging. Whole-brain regression analyses and prediction analyses showed that higher dispositional hope was stably associated with greater GMV in the left supplementary motor area (SMA). Furthermore, mediation analyses revealed that dispositional hope mediated the relation between left SMA volume and subjective well-being. Critically, our results were obtained after adjusting for age, sex, family socioeconomic status and total GMV. Altogether, our study presents novel evidence for the neuroanatomical basis of dispositional hope and suggests an underlying indirect effect of dispositional hope on the link between brain gray matter structure and subjective well-being.

中文翻译：

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希望与神经结构相关：性欲希望介导SMA灰质体积对青春期晚期主观幸福感的影响。

在过去的二十年中，人们越来越关注确定积极的心理学领域中预测主观幸福感的因素。反映了一个人的目标导向倾向的性格希望已成为主观幸福感的稳定预测因素，包括路径思维（计划实现目标）和代理思维（目标导向的决心）。但是，尚不清楚性格希望的神经生物学底物和预测主观幸福感的大脑希望机制。在这里，我们通过使用基于结构磁共振成像的基于体素的形态计量方法估算皮层灰质体积（GMV）来评估同一年级的231名高中毕业生的这些问题。全脑回归分析和预测分析表明，更高的处置希望与左辅助运动区（SMA）的更大GMV稳定相关。此外，调解分析显示，性格的希望介导了左SMA量与主观幸福感之间的关系。重要的是，我们的结果是在调整了年龄，性别，家庭社会经济地位和总GMV之后得出的。总之，我们的研究为性格希望的神经解剖学基础提供了新的证据，并提出了性格希望对大脑灰质结构与主观幸福感之间潜在的间接影响。调解分析显示，性欲希望介导了左SMA量与主观幸福感之间的关系。重要的是，我们的结果是在调整了年龄，性别，家庭社会经济地位和总GMV之后得出的。总之，我们的研究为性格希望的神经解剖学基础提供了新的证据，并提出了性格希望对大脑灰质结构与主观幸福感之间潜在的间接影响。调解分析显示，性欲希望介导了左SMA量与主观幸福感之间的关系。重要的是，我们的结果是在调整了年龄，性别，家庭社会经济地位和总GMV之后得出的。总之，我们的研究为性格希望的神经解剖学基础提供了新的证据，并提出了性格希望对大脑灰质结构与主观幸福感之间潜在的间接影响。