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Quantification of Brominated Polycyclic Aromatic Hydrocarbons in Environmental Samples by Liquid Chromatography Tandem Mass Spectrometry with Atmospheric Pressure Photoionization and Post-column Infusion of Dopant.
Analytical Sciences ( IF 1.6 ) Pub Date : 2020-09-10 , DOI: 10.2116/analsci.20p025
Misato Masuda 1 , Qi Wang 1 , Masahiro Tokumura 1 , Yuichi Miyake 1 , Takashi Amagai 1
Affiliation  

A sensitive method for the quantification of brominated polycyclic aromatic hydrocarbons (BrPAHs) in environmental samples is yet to be developed. Here, we optimized the analytical conditions for liquid chromatography tandem mass spectrometry with atmospheric pressure photoionization and post-column infusion of dopant (LC-DA-APPI-MS/MS). We then compared the sensitivity of our developed method with that of conventional gas chromatography high-resolution MS (GC-HRMS) by comparing the limits of quantification (LOQs) for a range of BrPAHs. Finally, to evaluate our developed method, 12 BrPAHs in sediments and fish collected from Tokyo Bay, Japan, were analyzed; 9 common PAHs were also targeted. The LOQs of the developed analytical method were 14 – 160 times lower than those of GC-HRMS for the targeted BrPAHs. The developed analytical method is a sensitive approach for determining the concentrations of BrPAHs in sediment and fish samples.

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中文翻译:

通过液相色谱串联质谱法、大气压光电离和柱后注入掺杂剂对环境样品中的溴化多环芳烃进行定量。

目前尚未开发出一种灵敏的方法来定量环境样品中的溴化多环芳烃 (BrPAH)。在这里,我们优化了常压光电离和柱后注入掺杂剂的液相色谱串联质谱 (LC-DA-APPI-MS/MS) 的分析条件。然后,我们通过比较一系列 BrPAH 的定量限 (LOQ),将我们开发的方法的灵敏度与传统气相色谱高分辨率 MS (GC-HRMS) 的灵敏度进行比较。最后,为了评估我们开发的方法,对从日本东京湾收集的沉积物和鱼类中的 12 种 BrPAH 进行了分析;9 种常见的 PAH 也成为目标。对于目标 BrPAH,所开发的分析方法的 LOQ 比 GC-HRMS 的 LOQ 低 14 – 160 倍。所开发的分析方法是测定沉积物和鱼类样品中 BrPAH 浓度的灵敏方法。

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更新日期:2020-09-12
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