Abstract

Ten cucurbitane-type triterpene glycosides, including five new compounds named charantosides H (1), J (2), K (3), momorcharacoside A (4), goyaglycoside-l (5), and five known compounds (6–10), were isolated from the EtOAc extract of Momordica charantia fruits. The chemical structures of these compounds were identified by 1D and 2D NMR and HRESIMS spectroscopic analyses. Configurations of new compounds were determined by ROESY correlations and comparison of their ¹³C NMR data with literature reported values. All compounds were evaluated for their inhibition against α-glucosidase, in which compounds 2, 5, 7, 8, 9 showed moderate inhibitory activities with IC₅₀ values ranging from 28.40 to 63.26 μM comparing with the positive control (acarbose, IC₅₀ 87.65 ± 6.51 μM).

Graphic Abstract

中文翻译：

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苦瓜的葫芦烷型三萜糖苷及其对α-葡萄糖苷酶的抑制活性。

摘要

十个葫芦素型三萜糖苷，包括五个新的化合物，分别名为charantosides H（1），J（2），K（3），苦瓜糖苷A（4），goyaglycoside- 1（5）和五个已知的化合物（6-10）。从苦瓜 果实的EtOAc提取物中分离出苦参。通过1D和2D NMR和HRESIMS光谱分析鉴定了这些化合物的化学结构。通过ROESY相关性确定新化合物的构型，并将其¹³ C NMR数据与文献报道的值进行比较。评价所有化合物对α的抑制作用葡糖苷酶，其中，化合物2，5，7，8，9显示中等抑制活性与IC _50个值范围从28.40到63.26μM与阳性对照进行比较（阿卡波糖，IC ₅₀ 87.65±6.51μM）。

图形摘要