Carbapenem resistance in Enterobacteriaceae has become an increasingly worrying threat. So far, no epidemiological data regarding NDM-producing enterobacterial isolates has been available on these strains in West Africa. The aim of this study was to seek for carbapenemase-producing Enterobacteriaceae clinical strains isolated in Bamako Teaching Hospital in Mali. Of 50 strains isolated between May 2016 and September 2016, we found a ST448 E. coli harbouring an IncX3 plasmid with bla NDM-5 embedded in the ΔISAba125-ble MBL structure. This study reports the first description of NDM-5 in Mali isolated in an undescribed ST E. coli in West Africa.

中文翻译：

---

对马里大肠杆菌ST448中产生IncX3 NDM-5的质粒的首次描述。

肠杆菌科对碳青霉烯的耐药性已成为日益令人担忧的威胁。到目前为止，在西非尚无有关生产NDM肠杆菌的流行病学数据。这项研究的目的是寻找在马里巴马科教学医院分离出的产生碳青霉烯酶的肠杆菌科临床菌株。在2016年5月至2016年9月之间分离的50株菌株中，我们发现了一个ST448大肠杆菌，其带有一个IncX3质粒，其bla NDM-5嵌入ΔISAba125-bleMBL结构中。这项研究报告了在西非未描述的ST大肠杆菌中分离的马里对NDM-5的首次描述。