Objective . Retinal prostheses aim to restore vision in patients with retinal degenerative diseases, such as age-related macular degeneration and retinitis pigmentosa. By implanting an array of microelectrodes, such a device creates percepts in patients through electrical stimulation of surviving retinal neurons. A challenge for retinal prostheses when trying to return high quality vision is the unintended activation of retinal ganglion cells through the stimulation of passing axon bundles, which leads to patients reporting large, elongated patches of light instead of focal spots. Approach. In this work, we used calcium imaging to record the responses of retinal ganglion cells to electrical stimulation in explanted retina using rectangular electrodes placed with different orientations relative to the axon bundles. Main results. We showed that narrow, rectangular electrodes oriented parallel to the axon bundles can achieve focal stimulation. To further improv...

中文翻译：

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使用定向矩形电极最大程度地减少视网膜神经节细胞的轴突束激活。

目标。视网膜假体旨在恢复患有视网膜退行性疾病（例如与年龄有关的黄斑变性和色素性视网膜炎）的患者的视力。通过植入微电极阵列，这样的设备通过电刺激存活的视网膜神经元在患者体内产生感知力。当试图返回高质量视力时，视网膜假体面临的挑战是通过刺激的轴突束刺激视网膜神经节细胞的意外激活，这导致患者报告出现大而细长的光斑，而不是斑点。方法。在这项工作中，我们使用钙成像技术来记录视网膜神经节细胞对植入的视网膜中电刺激的反应，方法是使用相对于轴突束方向不同放置的矩形电极。主要结果。我们表明平行于轴突束定向的窄矩形电极可以实现局部刺激。为了进一步完善...