Viruses and cytolytic lymphocytes operate in an environment filled with dying and dead cells, and cell fragments. For viruses, irreversible fusion with doomed cells is suicide. For cytotoxic T lymphocyte and natural killer cells, time and limited lytic resources spent on apoptotic targets is wasteful and may result in death of the host. We make the case that the target membrane cytoskeleton is the best source of information regarding the suitability of potential targets for engagement for both viruses and lytic effector cells, and we present experimental evidence for detection of apoptotic cells by HIV, without loss of infectivity.

中文翻译：

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病毒和细胞溶解性淋巴细胞对凋亡细胞的识别：战争迷雾中的目标选择。

病毒和溶细胞性淋巴细胞在充满垂死和死细胞以及细胞碎片的环境中运行。对于病毒，与注定细胞的不可逆融合是自杀。对于细胞毒性T淋巴细胞和自然杀伤细胞，在凋亡靶标上花费的时间和有限的裂解资源是浪费的，并且可能导致宿主死亡。我们认为靶膜细胞骨架是有关潜在靶标是否适合病毒和裂解效应细胞参与的信息的最佳信息来源，并且我们提供了在不损失感染力的情况下通过HIV检测凋亡细胞的实验证据。