Occupational exposure to lead is one of the important hazards to human global population. Lead interferes with divalent cations, such as calcium, magnesium, and iron. Magnesium is the fourth most common mineral in the human body and a cofactor in more than 325 enzymes. There are many disorders associated with magnesium deficiency. It has been postulated that hypomagnesemia promotes oxidative stress. Study population included 232 male employees of lead-zinc works and was divided into two sub-groups based on the median of magnesium serum level: low magnesium level (L-Mg) group and high magnesium level (H-Mg) group. Magnesium level was significantly higher in the H-Mg group than in the L-Mg group due to the study design. The level of zinc protoporphyrin was significantly higher in the L-Mg group than in the H-Mg group by 13%, while the blood lead levels were similar in the examined groups. The serum level of MDA was significantly higher in the L-Mg group than in the H-Mg group by 12%, while the serum levels of thiol groups, TAC, and bilirubin were significantly lower in that group by 6%, 3%, and 27%, respectively. Similarly, the erythrocyte SOD activity was lower in the L-Mg group than in the H-Mg group by 5%. Low serum magnesium levels contribute to lead-induced oxidative stress, result in unfavorable modification of antioxidant system function, and promote lead-induced impairment of heme synthesis. Obtained results indicate that prevention of hypomagnesemia should be regarded as an important step in ensuring adequate prophylaxis of chronic lead poisoning.

中文翻译：

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铅暴露工人的血镁水平和选定的氧化应激指数。

职业性铅暴露是对全球人口的重要危害之一。铅会干扰二价阳离子，如钙、镁和铁。镁是人体第四大最常见的矿物质，也是超过 325 种酶的辅助因子。有许多与镁缺乏相关的疾病。据推测，低镁血症会促进氧化应激。研究人群包括232名铅锌厂男性员工，根据血清镁水平中位数分为两个亚组：低镁水平（L-Mg）组和高镁水平（H-Mg）组。由于研究设计，H-Mg 组的镁水平显着高于 L-Mg 组。L-Mg组锌原卟啉水平显着高于H-Mg组13%，而受检组的血铅水平相似。L-Mg 组血清 MDA 水平显着高于 H-Mg 组 12%，而硫醇组、TAC 和胆红素的血清水平显着低于该组 6%、3%、和 27%，分别为。类似地，L-Mg 组的红细胞 SOD 活性比 H-Mg 组低 5%。低血清镁水平有助于铅诱导的氧化应激，导致抗氧化系统功能的不利改变，并促进铅诱导的血红素合成受损。获得的结果表明，预防低镁血症应被视为确保充分预防慢性铅中毒的重要步骤。L-Mg 组血清 MDA 水平显着高于 H-Mg 组 12%，而硫醇组、TAC 和胆红素的血清水平显着低于该组 6%、3%、和 27%，分别为。类似地，L-Mg 组的红细胞 SOD 活性比 H-Mg 组低 5%。低血清镁水平有助于铅诱导的氧化应激，导致抗氧化系统功能的不利改变，并促进铅诱导的血红素合成受损。获得的结果表明，预防低镁血症应被视为确保充分预防慢性铅中毒的重要步骤。L-Mg 组血清 MDA 水平显着高于 H-Mg 组 12%，而硫醇组、TAC 和胆红素的血清水平显着低于该组 6%、3%、和 27%，分别为。类似地，L-Mg 组的红细胞 SOD 活性比 H-Mg 组低 5%。低血清镁水平有助于铅诱导的氧化应激，导致抗氧化系统功能的不利改变，并促进铅诱导的血红素合成受损。获得的结果表明，预防低镁血症应被视为确保充分预防慢性铅中毒的重要步骤。L-Mg 组的红细胞 SOD 活性比 H-Mg 组低 5%。低血清镁水平有助于铅诱导的氧化应激，导致抗氧化系统功能的不利改变，并促进铅诱导的血红素合成受损。获得的结果表明，预防低镁血症应被视为确保充分预防慢性铅中毒的重要步骤。L-Mg 组的红细胞 SOD 活性比 H-Mg 组低 5%。低血清镁水平有助于铅诱导的氧化应激，导致抗氧化系统功能的不利改变，并促进铅诱导的血红素合成受损。获得的结果表明，预防低镁血症应被视为确保充分预防慢性铅中毒的重要步骤。