The development of stimuli-responsive nanomaterials, that possess tailored functional properties for the release of specific compounds, is of particular interest. To this extent, controlling the release of molecules at the desired target is an important parameter to regulate chemical and/or biological reactions at a more profound level in a wide variety of applications. In the present work, we report on the development of dual-responsive thiourethane–urethane nanocapsules synthesized via an interfacial polymerization reaction executed at the droplet interface using the inverse miniemulsion technique. Evidence via morphological and controlled release investigations indicate that our nanocapsules are able to encapsulate hydrophilic compounds with high efficiency in their aqueous core and allow for its selective release upon exposure to UV light and the enzyme esterase. Moreover, we demonstrate the efficient encapsulation of the fragrance molecule geranyl acetate and the anticancer drug doxorubicin. For the latter, we demonstrate its apoptotic effect after being released in MCF 7 breast cancer cells. Overall, these nanocapsules can be used for a wide variety of applications where a selective release of the payload is desired.

中文翻译：

---

具有光响应和酶促触发作用的具有控释功能的纳米胶囊

具有用于释放特定化合物的量身定制的功能特性的刺激响应性纳米材料的开发尤其引起人们的兴趣。就此而言，在各种应用中，控制分子在所需靶标处的释放是在更深层次上调节化学和/或生物反应的重要参数。在目前的工作中，我们报告了通过使用逆细乳液技术在液滴界面上进行的界面聚合反应合成的双响应硫代氨基甲酸酯-氨基甲酸酯纳米胶囊的开发。证据通过形态学和控释研究表明，我们的纳米胶囊能够将亲水性化合物高效地包裹在其水核中，并使其在暴露于紫外线和酯酶后能够选择性释放。此外，我们证明了香精分子乙酸香叶酯和抗癌药阿霉素的有效封装。对于后者，我们证明了其在MCF 7乳腺癌细胞中释放后的凋亡作用。总体而言，这些纳米胶囊可用于需要选择性释放有效载荷的多种应用。