There is increasing evidence for the role of environmental endocrine disrupting contaminants, coined obesogens, in exacerbating the rising obesity epidemic. Obesogens can be found in everyday items ranging from pesticides to food packaging. Although research shows that obesogens can have effects on adipocyte size, phenotype, metabolic activity, and hormone levels, much remains unknown about these chemicals. This review will discuss what is currently known about the mechanisms of obesogens, including expression of the PPARs, hormone interference, and inflammation. Strategies for identifying obesogenic chemicals and their mechanisms through chemical characteristics and model systems will also be discussed. Ultimately, research should focus on improving models to discern precise mechanisms of obesogenic action and to test therapeutics targeting these mechanisms.

中文翻译：

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作用机理，化学特征和致肥胖物模型系统。

越来越多的证据表明，环境内分泌干扰污染物（造币的致病原）在加剧肥胖症流行中的作用。从杀虫剂到食品包装，日常物品中都含有致肥胖物。尽管研究表明，致肥胖物可能会影响脂肪细胞的大小，表型，代谢活性和激素水平，但对于这些化学物质仍知之甚少。这篇综述将讨论有关致肥胖物机制的当前已知信息，包括PPAR的表达，激素干扰和炎症。还将讨论通过化学特性和模型系统识别致肥胖化学物质的策略及其机理。最终，