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Cytotoxicity of acylphloroglucinol derivatives from the fruits of Horsfieldia irya
Natural Product Research ( IF 2.2 ) Pub Date : 2020-05-21 , DOI: 10.1080/14786419.2020.1749616
Jittra Suthiwong 1, 2 , Thurdpong Sribuhom 1 , Paweena Wongphakham 3 , Thanaset Senawong 3 , Chavi Yenjai 1
Affiliation  

Abstract

Four new acylphloroglucinol derivatives 1, 3, 5 and 13 were isolated from the fruits of Horsfieldia irya, and in addition, thirteen known compounds were also discovered. All compounds were evaluated for cytotoxicity against HeLa and HCT116 cell lines, as well as normal cells (Vero cells). Compound 13 showed cytotoxicity against HeLa and HCT116 cell lines with IC50 values of 4.53 ± 0.05 and 4.53 ± 0.16 μg/mL, respectively, and showed less activity against normal cells (IC50 = 13.38 ± 0.75 μg/mL). Compound 13 may be useful for the development of anticancer agents. It was found that decanoyl side chain may be necessary for the cytotoxicity. The chemical structures of all isolated compounds were elucidated using spectroscopic methods including 1 D-NMR, 2 D-NMR, MS and IR data.



中文翻译:

Horsfieldia irya 果实酰基间苯三酚衍生物的细胞毒性

摘要

四个新的酰基间苯三衍生物13513是从的果实中分离滇南风吹irya,并且另外,也被发现13种已知的化合物。评估了所有化合物对 HeLa 和 HCT116 细胞系以及正常细胞(Vero 细胞)的细胞毒性。化合物13对 HeLa 和 HCT116 细胞系显示出细胞毒性,IC 50值分别为 4.53 ± 0.05 和 4.53 ± 0.16 μg/mL,对正常细胞的活性较低(IC 50  = 13.38 ± 0.75 μg/mL)。化合物13可能有助于开发抗癌剂。发现癸酰基侧链可能是细胞毒性所必需的。所有分离化合物的化学结构均使用光谱方法阐明,包括 1 D-NMR、2 D-NMR、MS 和 IR 数据。

更新日期:2020-05-21
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