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Galectin-3: Roles in Neurodevelopment, Neuroinflammation, and Behavior.
Biomolecules ( IF 5.5 ) Pub Date : 2020-05-21 , DOI: 10.3390/biom10050798
Ivan Srejovic 1 , Dragica Selakovic 1 , Nemanja Jovicic 2 , Vladimir Jakovljević 1, 3 , Miodrag L Lukic 4 , Gvozden Rosic 1
Affiliation  

: There is a plethora of evidence to suggest that Galectin-3 plays an important role in normal functions of mammalian cells, as well as in different pathogenic conditions. This review highlights recent data published by researchers, including our own team, on roles of Galectin-3 in the nervous system. Here, we discuss the roles of Galectin-3 in brain development, its roles in glial cells, as well as the interactions of glial cells with other neural and invading cells in pathological conditions. Galectin-3 plays an important role in the pathogenesis of neuroinflammatory and neurodegenerative disorders, such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. On the other hand, there is also evidence of the protective role of Galectin-3 due to its anti-apoptotic effect in target cells. Interestingly, genetic deletion of Galectin-3 affects behavioral patterns in maturing and adult mice. The results reviewed in this paper and recent development of highly specific inhibitors suggests that Galectin-3 may be an important therapeutic target in pathological conditions including the disorders of the central nervous system.

中文翻译:

Galectin-3:在神经发育,神经炎症和行为中的作用。

有大量证据表明Galectin-3在哺乳动物细胞的正常功能以及不同的致病条件中起着重要的作用。这篇综述重点介绍了研究人员(包括我们自己的团队)发布的有关Galectin-3在神经系统中的作用的最新数据。在这里,我们讨论了Galectin-3在大脑发育中的作用,其在神经胶质细胞中的作用以及在病理条件下神经胶质细胞与其他神经和侵袭细胞的相互作用。Galectin-3在神经发炎和神经退行性疾病的发病机理中起重要作用,例如多发性硬化症,阿尔茨海默氏病,帕金森氏病和亨廷顿氏病。另一方面,由于Galectin-3在靶细胞中具有抗凋亡作用,因此也有证据表明其具有保护作用。有趣的是 Galectin-3的基因缺失影响成熟小鼠和成年小鼠的行为模式。本文综述的结果以及高度特异性抑制剂的最新进展表明,Galectin-3可能是包括中枢神经系统疾病在内的病理疾病的重要治疗靶标。
更新日期:2020-05-21
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