Posttranscriptional modification of mRNA sequences through RNA editing can increase transcriptome and proteome diversity in eukaryotes. Studies of fetal and adult tissues showed that adenosine‐to‐inosine RNA editing plays a crucial role in early human development, but there is a lack of global understanding of dynamic RNA editing during mammalian early embryonic development. Therefore, here we used RNA sequencing data from human, pig and mouse during early embryonic development to detect edited genes that may regulate stem cell pluripotency. We observed that although most of the RNA editing sites are located in intergenic, intron and UTR, a few editing sites are in coding regions and may result in nonsynonymous amino acid changes. Some editing sites are predicted to change the structure of a protein. We also report that HNF1A, TBX3, ACLY, ECI1 and ERDR1 are related to embryonic development and cell division.

中文翻译：

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通过全基因组比较揭示早期胚胎发育过程中猪特异性 RNA 编辑。

通过 RNA 编辑对 mRNA 序列进行转录后修饰可以增加真核生物的转录组和蛋白质组多样性。对胎儿和成人组织的研究表明，腺苷-肌苷 RNA 编辑在人类早期发育中起着至关重要的作用，但对哺乳动物早期胚胎发育过程中的动态 RNA 编辑缺乏全球了解。因此，我们在早期胚胎发育过程中使用来自人类、猪和小鼠的 RNA 测序数据来检测可能调节干细胞多能性的编辑基因。我们观察到，虽然大多数 RNA 编辑位点位于基因间、内含子和 UTR，但少数编辑位点位于编码区，可能导致非同义氨基酸变化。一些编辑位点预计会改变蛋白质的结构。我们还报告说HNF1A、TBX3、ACLY、ECI1和ERDR1与胚胎发育和细胞分裂有关。