Seminars in Cell & Developmental Biology ( IF 7.3 ) Pub Date : 2020-05-20 , DOI: 10.1016/j.semcdb.2020.04.013 Michaela Veliova 1 , Anton Petcherski 2 , Marc Liesa 3 , Orian S Shirihai 1
Proper regulation of cellular lipid storage and oxidation is indispensable for the maintenance of cellular energy homeostasis and health. Mitochondrial function has been shown to be a main determinant of functional lipid storage and oxidation, which is of particular interest for the adipose tissue, as it is the main site of triacylglyceride storage in lipid droplets (LDs). Recent studies have identified a subpopulation of mitochondria attached to LDs, peridroplet mitochondria (PDM) that can be separated from cytoplasmic mitochondria (CM) by centrifugation. PDM have distinct bioenergetics, proteome, cristae organization and dynamics that support LD build-up, however their role in adipose tissue biology remains largely unexplored. Therefore, understanding the molecular basis of LD homeostasis and their relationship to mitochondrial function and attachment in adipocytes is of major importance.
中文翻译:
脂滴结合线粒体的生物学。
细胞脂质储存和氧化的适当调节对于维持细胞能量稳态和健康是必不可少的。线粒体功能已被证明是功能性脂质储存和氧化的主要决定因素,这对脂肪组织特别感兴趣,因为它是脂滴 (LD) 中甘油三酯储存的主要部位。最近的研究已经确定了附着在 LDs 上的线粒体亚群,peridroplet 线粒体 (PDM),可以通过离心从细胞质线粒体 (CM) 中分离出来。PDM 具有独特的生物能量学、蛋白质组学、嵴组织和支持 LD 积累的动力学,但它们在脂肪组织生物学中的作用在很大程度上仍未得到探索。所以,